An avocado based supplement that targets glucose metabolism at the cellular level


SP Nutraceuticals Inc. was founded by people who want more out of natural health products. 

We want products that work, and in order to create products that work, you need to know what the bioactive molecule is, how it works and why it works. 

Metavo is a supplement with an efficacious dose of AvoB, a powerful bioactive molecule derived from avocado that was discovered and studied at the University of Guelph. 

The research team at the University of Guelph discovered AvoB, a powerful bioactive molecule found in avocados which targets insulin resistance. SP Nutraceuticals has taken this discovery and developed it further through regulatory approval, product formulation, stability and analytical testing and created a product, Metavo, that can help people with this condition.

Researchers led by Associate Professor Paul Spagnuolo have shown how a compound found only in avocados can inhibit cellular processes that normally lead to diabetes. In safety testing in humans, the team also found that the substance was absorbed into the blood with no adverse effects on the kidney, liver or muscle.

About one in four Canadians are obese, a chronic condition that is a leading cause of Type 2 diabetes. Insulin resistance in diabetic patients means their bodies are unable to properly remove glucose from the blood. 

Those complications can arise when mitochondria, or the energy powerhouses in the body’s cells, are unable to burn fatty acids completely.

Normally, fatty acid oxidation allows the body to burn fats. Obesity or diabetes hinders that process, leading to incomplete oxidation.

The University of Guelph researchers discovered that AvoB, a fat molecule found only in avocados, counters incomplete oxidation in skeletal muscle and the pancreas to reduce insulin resistance.

In their study, the team fed mice high-fat diets for eight weeks to induce obesity and insulin resistance. For the next five weeks, they added AvoB to the high-fat diets of half of the mice.

The mice treated with AvoB weighed significantly less than those in the control group, showing slower weight gain. More important, the AvoB treated mice showed greater insulin sensitivity, meaning that their bodies were able to absorb and burn blood glucose and improve their response to insulin. 

In a human clinical study, AvoB given as a dietary supplement to participants eating a typical western diet was absorbed safely into their blood without affecting the kidney, liver or skeletal muscle. The team also saw reductions in weight in human subjects treated with AvoB, although the result was not statistically significant.

SP Nutraceuticals Inc. now plans to conduct clinical trials to test AvoB’s efficacy in treating metabolic ailments in people with insulin resistance.

The importance of the safety trial was to help our team determine the dose of AvoB to include in the supplement formulation in order to ensure efficacy.

As many people often ask us, will eating avocados have the same effect?  Eating avocados alone would likely be ineffective, as the amount of natural AvoB varies widely in the fruit and we still do not fully understand exactly how AvoB is digested and absorbed when we consume a whole avocado. We continue to encourage eating avocados as part of a healthy diet, especially for those who require low carb/sugar foods.

Although avocados have been touted as a weight-loss food, more study is needed. A healthy diet and exercise are recommended to prevent metabolic disorders leading to obesity or diabetes.


Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity